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In scientific literature, NNMT is recognized as an enzyme that methylates nicotinamide (a precursor of NAD+) using S-adenosylmethionine (SAM) as the methyl donor, converting it to 1-methylnicotinamide (MNA) and potentially affecting cellular NAD+ availability

GSH-independence can be conferred by mutations at the protomer interface, consistent with GSH binding to protomers driving the formation of pentameric units critical to assembly 16,17

The complex increases the level of cytoplasmic ROS, which is detected by MPO

Post-surgical applications often follow similar patterns

This is Daves second time on the podcast, and its a nuanced exploration of what it means to live with vitality and consciousness in a world obsessed with optimization