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46(1): 779 Sanders-Bush E, Mayer SE

Biochem Pharmacol (2005) 70(2):2008

It also contains a balance of electrolytes like sodium, calcium & potassium - unlike Normal Saline which is just salt water

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In addition, the energy required to break the Cu 2+ /imidazolyl coordination bond is not the lowest in comparison to Cu 2+ /carboxyl and Cu 2+ /amino coordination, leading to a negative impact on the catalytic activity also 28,29