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Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial 35% decrease (P 30% decrease in adipocyte size (P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice

Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development

The STEP 1 trial of injectable semaglutide 2.4 mg reported a 7.0% discontinuation rate due to adverse events

Such recommendations would be inconvenient for many people and could lead to some cases of acne-like symptoms in people sensitive to high doses of B12 (see Footnote B in Elevated Vitamin B12 Levels and Mortality)