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This could suggest that higher doses of pramlintide might be necessary to achieve significant weight loss, although it is not yet clear whether concurrent insulin treatment was the main cause of that difference

In comparison to other BV-binding photoreceptors, notably the bacteriophytochromes, the photocobilins lack the Cys residue that covalently links to the BV molecule and is essential for light-induced cis-trans isomerisation 16,17,18 (Figs