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However, these specifically targeted elements within the design that benefit from the implementation of Predictive Maintenance technologies, are ultimately only individual actors within the much broader integrated system

These structural alterations are most pronounced in regions critical for higher-order cognition, including the PFC and the hippocampus 104 (Table 4)

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Gln67 of TNF- also donates an h-bond to the carbonyl of VNAR-C4 Thr89, forming a backbone-backbone interaction common among VNARs 24

Although a plethora of macrophage phenotypes has been identified by the advent of single cell biology - amongst others resident macrophages, TNF + pro-inflammatory macrophages, IL1 + pro-inflammatory macrophages, Trem2 + macrophages, lipid-associated Trem2 hi-perilipin + macrophages, and IL10 + TNFAIP3 + macrophages (de Winther et al., 2023