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Interestingly, NAC has been used in medicine for decades as a treatment for paracetamol overdose and is recognised by the WHO as an essential medicine

193,194 Tryptophan produced from lung fungi is converted to kynurenine by host indoleamine 2,3-dioxygenase, which causes an increase in Treg cells and a downregulation of Th17-mediated mucosal inflammation

Initially, NOX2 activation generates significant quantities of H 2 O 2 /O, which subsequently activate key signaling pathways such as MAPK and JNK, leading to nuclear membrane breakdown and chromatin decondensation, culminating in NET formation

Ramya et al., 2022b

Cohort entry was defined as the date of the first-ever prescription for statins (statin users)