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For instance, although initial improvements were observed over 18 weeks or longer, these effects were not maintained after discontinuation in many cases

Most people see immediate benefits on the skin, often times lightening or whitening the skin complexion to a more desireable skin tone

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Acitretin, on the other hand, carries an increased risk of hepatotoxicity when combined with alcohol, as it converts into etretinate, the more toxic and persistent metabolite

Furthermore, the catalytic mechanism, which is dependent on proton-dependent oxidation, cannot act on trimethylated lysine