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Inhibition of TNF-a-induced nuclear translocation of the NF-B p65 subunit by WA has been demonstrated in human lung epithelial cells [110, 111]

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This suggests that Grx1 may regulate TDP-43 protein stability through mechanistically distinct pathways, potentially involving redox-dependent posttranslational modifications such as S-glutathionylation that directly influence TDP-43 protein stability

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Various in vitro and in vivo studies have confirmed the antidiabetic, hypolipidemic, hypotensive, neuroprotective, and cardioprotective properties