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Science (2014) 343:12603

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When all is said and done, the body may not fully absorb the entire dose, and it can take time to feel the effects

Cobalamin Supplementation There are two primary routes: Parenteral (Injection) 2501,000 g subcutaneously once weekly for 46 weeks Followed by monthly maintenance if required Oral (Cyanocobalamin or Methylcobalamin) High-dose oral B12 (e.g., 250500 g/day) can be effective even in dogs with malabsorption due to passive diffusion Methylcobalamin may be more bioavailable, though veterinary research is still emerging 2