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This pathway involves inflammatory caspases, intracellular pattern recognition receptors (PRRs), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1 [81]

10.1111/j.1471-4159.2006.03742.x J

Baxter, P

In parallel, HMC3 cells secrete neurotrophic and angiogenic factors, including BDNF, vascular endothelial growth factor-a (VEGF-A), and insulin-like growth factor-binding protein-1 (IGFBP-1), contributing to neurovascular cross-talk, although amyloid exposure suppresses BDNF release, linking metabolic stress to impaired neuroprotective output (218)