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Now, inspired by the mitochondria-focused genetic interaction map in Saccharomyces cerevisiae 11 and the known influence of environment on genetic interactions 12 , we sought a dual genetic perturbation approach to probe the human SLC25 transporters under different metabolic states 13

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

Based on these findings, we propose that the multiple cell death pathways induced by Erastin in EMS create a tightly regulated positive feedback network centered around free iron and ROS

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