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Following activation by redox signaling downstream of the MAPK signal pathway, the EpRE binding protein, also an oxidative stress-associated transcription factor, induces the dissociation of Nrf2 from Keap1 via redox modification and/or phosphorylation of Nrf2

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Abbreviations ADI-R: Autism diagnostic interview - revised ALAD: Delta aminolevulinic acid dehydratase CARS: Childhood Autism Rating Scale CNS: Central nervous system d.f.: Degrees freedom DSM: American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders fGSH: Free reduced glutathione GCL: Glutamate cysteine ligase GCT: -glutamyl cyclotransferase GGT: -glutamyl-transferase GPx: Glutathione peroxidase GSH: Reduced glutathione GSH: GSSG: Glutathione redox ratio GSH-R: Glutathione reductase GS: Glutathione synthetase GSSG: Oxidised glutathione GST: Glutathione-S-transferases Mg 2+ : Magnesium ions Mn 2+ : Manganese ions Q: Cochran's Q (a measure of statistical heterogeneity) SMD: Standardised mean difference tGSH: Total glutathione References Wing L, Gould J: Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification

In a separate study, ASTA demonstrated no toxicity in human cells at low concentrations, although high concentrations of ASTA in the culture medium led to reduced neutrophil viability