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[1] Although water-soluble vitamins are generally excreted through urine when consumed in excess, vitamin B12 is unique in that significant amounts are stored in the liver

What matters is the resulting concentration: extremely dilute solutions (under ~0.5 mg/mL) require larger injection volumes per dose, which becomes uncomfortable and can shift absorption kinetics

Reported side effects include mild nausea, fatigue, dizziness, and temporary injection site irritation

Bevacizumab inhibited T-cell proliferation, attenuated vascular response, and reduced angiogenesis (MacMillan and Furlong 2012)

Special attention should also be paid to the usage cycle and storage