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The following sections briefly introduce these signaling pathways and their molecular drivers

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Intradiscal delivery of celecoxibloaded microspheres restores intervertebral disc integrity in a preclinical canine model

Since glucocorticoids are known to mediate inhibition of NF-kB (beneficially modulated by certain antioxidants such as thiols), adjunctive therapy with an effective thiol donor (e.g., NAC or SAMe) and vitamin E may optimize control of inflammatory mediator release and cell response as compared to pure immunomodulatory treatment or therapy limited to antioxidants

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