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In normal healthy animals, the peptide increases lower esophageal sphincter pressure while actually decreasing pyloric sphincter pressure

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Enzyme-catalyzed activation of anticancer prodrugs

Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA

GABA is transported into presynaptic neurons via the GABA transporter type 1 (GAT-1), while the vesicular inhibitory amino acid transporter (VIAAT) utilizes the proton gradient generated by the vacuolar-type ATPase to transport GABA into synaptic vesicles