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observed that in the Frda/MCK mouse model, the initial phenotype after frataxin repression was the downregulation of Fe-S-dependent enzymes, which was then followed by iron accumulation [62]

Half-life experiments in WT Balb/c mice (Taconic Farms) (6 mice/group, 8 weeks old) were performed at Oslo University Hospital animal facility

The pretraining comprised of four sessions on three successive days adopting an accelerating protocol that began at 5 rpm and increased to 20 rpm in 5 min

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Drawing on her personal story and clinical insights, Dr