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Maintenance treatments are usually less frequent and less intense than the initial course of injections but can be necessary to sustain the desired effects

Recent studies have indicated that lysosomes are the primary centers of metabolic signaling pathways, have critical involvement in nutrient sensing, and are capable of monitoring the cellular metabolic state and further facilitate adaption to nutrient deprivation by activating mTORC1 and AMPK 37,38,39 (Fig

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Thus, the products of lipid peroxidation, protein carbonylation and DNA oxidation can serve as potential biomarkers