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It is also an inhibitor of topoisomerases I and II in cancer cells (Hoernlein et al., 2000

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Consistent with this report, we found that palbociclib was a poor inhibitor of cyclin D1-CDK4-p27 trimers (Fig

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Some studies suggest there is a limited reservoir of melanocytes up there

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Additionally, Nrf2 knockout mice are more sensitive to mitochondrial complex inhibitors such as MPTP and 3-nitropropionic acid [108], suggesting an important role of this transcription factor in scavenging free radicals

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