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10.1093/jxb/erq282 62 MhamdiA.HagerJ.ChaouchS.QuevalG.HanY.TaconnatL.et al

International journal of molecular sciences , 12 (8), 52135237

Mittler and Zilinskas 1991)

Stan Kubow for reviewing this manuscript and for providing endless support

Double pathology of vitamin B12 deficiency B12 deficiency leads to the inactivation of methionine synthase (MS), and 5- methyl -THF cannot be utilized, which leads to the stagnation of folic acid cycle (the accumulation of intracellular 5-MTHF increases by 300%) and inhibits purine synthesis