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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

This situation has become more common as regulatory oversight tightens around compounded weight loss medications

The study did conclude that those who took B12 supplements were unlikely to have deficient or low B12 levels

Meanwhile, the Adelaide University medical researcher who led the six clinical trials from 2001 to 2007 has expressed his regret that the ''negative data'' was not published soon after the trial was completed

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