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In each case, the rebinding of dissociated nascent peptide/DNA or peptide/RNA complex is prevented, and with increasing time, nascent peptide/DNA or peptide/RNA complexes of higher and higher affinity are recovered

Their ability to regulate inflammatory responses and key signaling pathways make them potential therapeutic agents for treating renal fibrosis

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During the activation stage, ROS can promote the assembly and activation of the NLRP3 inflammasome, and thioredoxin-interacting protein (TXNIP) plays an important role in this process

Cell 160 , 10611071 (2015)