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Mechanical loading of the disc initiates cell-mediated remodeling events that lead to disc degeneration 59,60

DOI: 10.1007/s00125-003-1036-5 33

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Yes, for dilution arithmetic

Third, they can also inhibit the activity of SAH hydrolase, a key enzyme for methyl donor recycling, thus decreasing the level of both DNA and histone methylation (Wyczechowska and Fabianowska-Majewska, 2003)