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As both IBD and PD have compromised intestinal barrier functions, DJ-1 deficiency promotes cytokine-mediated inflammation (IL-1, IL-6, TNF, and TGFB1) and apoptosis of intestinal epithelial cells via a p53-dependent mechanism in vitro , in ex vivo colonic sacs, and in vivo (van IJzendoorn and Derkinderen, 2019

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Additionally, there is the potential to modify the underlying disease with IL-23 inhibitors

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