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These studies position lactylation as a crucial player in the pathophysiological processes of various diseases, significantly expanding our understanding of the role of lactate in disease contexts

Since a number of kinases such as protein kinase N (PKN) and the mitogen-activated protein kinase (MAPK) p38 are known to be sensitive to cellular stress conditions, such as changes in osmolarity, it is also conceivable how stress-induced signal cascades could lead to alterations in the uptake of specific proteins by introducing the phosphorylation of cargo or adaptor proteins

Combination of linsitinib and the ER antagonist fulvestrant is more effective to inhibit hormone-independent breast cancer growth than the single agent [108]

Dispersive pipette extraction and HPLC-DAD for the determination of polyphenols in grape juice

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