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Description

10.1016/j.brainres.2015.09.034 177 PatelS

DSIP is administered subcutaneously, just beneath the skin, typically in the abdominal area

Norepinephrine released at the pineal gland activates beta-1 adrenergic receptors, which upregulate cyclic AMP (cAMP)

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Human induced pluripotent stem cell culture Human induced pluripotent stem cells (hiPSCs) lines, IMR90 (IMR90-4/WISCi004-B, RRID:CVCL_C437, WiCell), M001 (SCTi002-A, RRID:CVCL_9S50, STEMCELL Technologies Inc.), and Gibco (TMOi001-A, RRID:CVCL_RM92, Gibco Episomal hiPSC Line, Gibco) were routinely cultured on 5 g/mL human laminin 521 (Biolamina)-coated culture-treated six-well plates (CoStar), maintained in mTeSR Plus (STEMCELL Technologies) supplemented with 1% (v/v) Pen-Strep