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The sections were counterstained with hematoxylin and evaluated by light microscopy (OLYMPUS-cell Sens Standard)

Another model of hyperalgesia is the mu opioid receptor agonist-induced hyperalgesia via stimulation cAMP by PLC and the phosphoinositide signaling cascade which specifically increases prkcg activity (Park et al., 1993)

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This multifunctionality represents a paradigm shift, transforming hydrogels from passive spacers into active modulators of the tumor microenvironment, directly addressing the spatial, biological, and biochemical limitations that have historically constrained brachytherapy efficacy