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Semaglutide has recently been reported to promote NASH resolution (Newsome et al., NEJM, 2020) and is currently in phase 3 clinical trial (ESSENCE) for NASH

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Se, primarily through its incorporation into selenoproteins, plays a significant role in modulating these processes

Spermine and MDA level (right) in liver tissues from administered with Vehicle or YG1702 with the indicated treatments at 6 m [n = 7 tumor tissues (Vehicle), n = 10 liver tissues (YG1702+Vehicle), n = 10 tumor tissues (YG1702+Spm), n = 10 tumor tissues (YG1702+Lip-1]