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This increased activity of AP-1 will lead to reduced collagen synthesis due to lower production of collagens I and III

PilE is, in fact, the core structural protein of Type IV pili, while PilC is the adhesin located at the top of the pilus, which is the most crucial factor for initial adhesion of meningococci to host cells (Virji et al., 1992

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This classification includes subtypes MCD ( MYD88L265P and CD79B mutations), BN2 ( BCL6 fusions and NOTCH2 mutations), N1 ( NOTCH1 mutations), EZB ( EZH2 mutations and BCL2 translocations), ST2 (PI3K signaling and JAK2 signaling), A53 (low p53 target genes), and TP53Mut (p53 signaling dysregulation, immune deficiency, and PI3K activation), each associated with different therapeutic responses and outcomes (150)

Wang X, Mak PY, Mu H, Jiang X, Mak D, Pachter JA, Weaver DT, Xu B, Andreeff M , Carter BZ