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Below, we detail various elements of a mechanism for ceramides in DKD: Figure 2 Lipid Accumulation Transcriptomic analyses of kidney biopsies from human patients have revealed elevated expression of SREBF and CD36 in the setting of DKD, which facilitate transcriptional upregulation of genes involved in de novo lipogenesis, triglyceride synthesis, and lipid uptake (70)

While the BBB is essential for maintaining CNS homeostasis, it severely restricts drug delivery

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