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15,18 Moreover, CYP2D6*36 which is gene conversion (GC) or hybrid between CYP2D7 pseudogene and CYP2D6 ( CYP2D6-2D7 ) in exon 9 results in nonfunctional CYP2D6 enzyme activity

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Patients in all studies had moderate-to-severe OCD (DSM-III), with mean baseline ratings on the Yale-Brown Obsessive Compulsive Scale (YBOCS) ranging from 26 to 28 and a mean baseline rating of 10 on the NIMH Clinical Global Obsessive Compulsive Scale (NIMH-OC)

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Another plausible mechanism by which CLA modulates body composition and weight loss is related to PPARs, especially PPAR, as CLA can reduce the expression of lipogenesis-related genes and decrease body fat by inhibiting PPAR [92]

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