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Tumor-associated macrophages (TAMs), which are infiltrating macrophages in tumor tissues, can be divided into M1-type macrophages that inhibit tumor growth and M2-type macrophages that promote tumor growth

J Proteome Res 9 , 144163, doi: 10.1021/pr900831f (2009)

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Additionally, the immune system can identify siRNA as foreign RNA, prompting the production of cytokines and interferons that cause off-target effects and toxicity