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There were some minor complications in four cases: one had erythema that continued to the next day and three had minor blisters leaving no marks

In individuals with obesity, both the mRNA levels and protein expression of FoxO1 were significantly increased compared to their non-obese counterparts (253)

Dec 2012;29(5):3626-33

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This is most commonly used to describe clinical situations in which a single dose of methylene blue produces only a transient and sometimes incomplete effect, with methemoglobin fractions never falling to near zero, and/or rebounding back up into a range of concern