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Costimulatory signals Costimulatory signals, originating predominantly from APCs, play a fundamental role in driving T cell differentiation amid inflammation conditions [44]

Thus, owing to the large surface area to volume ratio of NPs and thanks to the wide range of surface functionalization that can be done through different chemical groups, these nanocarriers can provide a great variety of interesting possibilities to overcome the BBB obstacle, with better results compared to traditional therapeutic approaches

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We examined the transcriptomic and metabolic responses of a glutathione synthetase mutant strain ( gsh ) exposed to iron supplementation, integrating these data into a genome-scale metabolic model (GSMM)

Compartmentalization of ROS production and antioxidant defense Nature has developed a system of cellular ROS/antioxidant compartmentalization mechanisms that ensure that redox homeostasis is maintained by the activity of ROS-producing/degrading systems