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On the day 1 and day 22 of dosing, time-coursed samples were measured using a validated detection method with sandwich ELISA (data not shown due to the limited contents in the manuscript)

Not necessarily, but dosing frequency below once daily during the induction phase may reduce cumulative receptor activation and limit the magnitude of neuroplasticity changes

In PD, researchers are examining if gut microbiome composition associates with markers like alpha-synuclein in colonic biopsies or with REM sleep behavior disorder severity (a prodromal feature)

That is not its mechanism or its clinical application

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