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All observed associations between patient characteristics and MELD-3 trajectory may reflect natural disease course, concurrent standard-of-care interventions, or regression to the mean rather than any pharmacological effect of glutathione

Burton AR, Pallett LJ, McCoy LE, Suveizdyte K, Amin OE, Swadling L, et al

( Reference Dutta, Seirafi and Halpin 39 ) , although riboflavin deficiency alone did not affect the activities of GPx and GR and increased the content of glutathione in the liver, ethanol administration (which can exacerbate oxidative stress) significantly decreased the activities of these enzymes and the content of glutathione in the liver of riboflavin-deficient rats compared with those in the liver of the riboflavin-sufficient control rats

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Genes associated with oxidoreduction, detoxification and mitochondria are under positive selection (Sahm et al., 2018b), and differentially expressed (Yu et al., 2011