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2025;11(44):eady4492.[DOI] 216

The Sdhc gene encoding a subunit of the succinate dehydrogenase enzyme, important in regulating electron flow through the ETC, was significantly upregulated in the AC-like cell state model, as were several thioredoxin genes involved in critical redox reactions ( Txn1, Txn2 ) (Fig

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CMS is committed to looking holistically at the concerns raised by the commenter across settings of care and will consider how to address for future rulemaking or guidance, and we thank the commenter for continuing to share firsthand experiences