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Without enough folate, cells can get damaged, and the body may rely more on glucose for energy instead of breaking down proteins and fats

IM injection is generally preferred for larger injection volumes (typically 0.5-2mL) as muscle tissue accommodates greater fluid volumes with less discomfort than subcutaneous fat

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2023, doi:10.3390/nu15030563 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

Thus, only about 50% of a rectal dose can be assumed to bypass the liver