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Although more RCTs are needed to draw convincing conclusions about efficacy in FM, antidepressants in monotherapy or in combination with a2d ligands are considered a valid treatment option for patients with FM

It helps the body to produce energy more efficiently

doi: 10.1155/2020/1452696 [DOI] [PMC free article] [PubMed] [Google Scholar] 89

This relationship provides further evidence that an autoimmune mechanism may be involved, given that the relationship between certain HLA-II alleles and autoimmune diseases is widely recognized (95)