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10.1038/s41586-024-07530-w Nature 13 LobritzM

Preclinical studies show that HG can reduce the infiltration of leukocytes by downregulating adhesion molecules and chemokines, leading to less inflammation and potentially less tissue damage in many critical conditions [8,9,10, 20, 32]

To reduce the effects of nonlinear error growth and prevent additional analysis drifter bias from influencing the DA performance (Salman 2008a,b), the initial drifter positions at the beginning of each 6-h time window are relocated by using the observed drifter positions, and the forecast ensemble drifter positions are generated by integrating the analysis flow ensemble at the end of previous DA step