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Description

Progesterone Progesterone (P4) is a C21 steroid hormone produced after ovulation by the corpus luteum of the ovary and, during pregnancy, by the placenta (with smaller amounts from the adrenal cortex)

Mechanistically, TXNIP antagonizes Trx1 by forming a disulfide bond with its Cys32 residue, leading to Trx1 inactivation and increased ROS levels, thereby facilitating lipid peroxidation and ferroptotic signaling