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A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit

Khadke et al

J., Clifford, T., Harper, L

180,181 Because SHBG binds to sex hormones and reduces their bioavailability, decreased SHBG levels lead to increased androgen signaling and is closely associated with both ovarian dysfunction and metabolic disturbance