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The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

While NAMPT activators show promise in preclinical studies, they are yet to enter clinical trials

Interestingly it was shown that in patients with Crohn's disease, IECs failed to produce TSLP, with consequent inability to control IL-12, produced by dendritic cells and involved in the development of Thelper 2 cells, resulting in alteration of intestinal homeostasis (346)