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Although the exact cause of paresthesia is unknown, it is thought to be due to BA activated strychnine-sensitive glycine receptor sites, associated with glutamate sensitive N-methyl-D-aspartate receptors in the brain and central nervous system (53) and the mas-related gene family of G protein coupled receptors, which are triggered by interactions with BA (54)

It is important to verify the cancer promoting role of Nrf2 observed in cancer cell lines and tumor biopsies, using in vivo animal models (106)

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However, a significant shift in theTrx1-reduced/Trx1-oxidized ratio towards Trx1-oxidized was observed when measured using redox western blotting technique

Reactive oxygen species: oxidative damage and pathogenesis