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Changes in appearance were also reported which was temporary [158]

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A central mechanism driving such pathological scarring is the persistent activation of the transforming growth factor-beta (TGF- )/Smad signaling pathway, which continuously stimulates fibroblasts and myofibroblasts, resulting in excessive collagen deposition and fibrotic remodeling (31, 32)

The liver generally oxidises xenobiotics and produces glucuronic acid, sulfate or glutathione conjugates