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Methods The PRISMA with PERSiST guidelines were followed for this systematic literature review, which was conducted in December 2023 using PubMed, Scopus, CINAHL, and SPORTDiscus databases

A formula that addresses only one a berberine product that targets glucose, or a thermogenic that raises heart rate leaves the larger metabolic picture unaddressed

Personalized medicine approaches should be explored, taking into account individual differences in the processes of development of the discussed diseases in response to the applied treatment

Understanding your genetic predispositions in peptide pathways and baseline inflammatory markers can help inform a more informed conversation with your provider about whether combination approaches or targeted supplementation align with your biology

Selected studies focused on classical probiotics ( Lactobacillus and Bifidobacteria spp.) and future studies utilizing next-generation probiotics with a higher potential to synthesize biologically relevant metabolites could have better treatment outcomes [125]