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The strongest predictors are baseline IGF-1 level, age, sleep quality (7-9 hours nightly), training consistency (4-6 days/week), diet quality, and protocol adherence

IGF-1 also affects protein synthesis via myostatin signaling, and the mechanism is discussed below

She explains that menopausal women often show an increase of antioxidant capacity as well as lower glutathione levels along with high levels of oxidative damage. According to Tennant, this rise in antioxidant capacity may be compensatorya protective response as the body ramps up defenses to counteract mounting oxidative stress.Since glutathione levels decrease while oxidative stress increases, its reasonable to consider supplementing with glutathione or NAC, alongside lifestyle interventions like exercise, diet, sleep, stress management, and possibly hormone replacement therapy, Tennant says

Even more importantly, when our glutathione levels are low, were at increased risk for aging faster than necessary, illness, and struggling to detox