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[DOI] [PubMed] [Google Scholar] 258.Grenha A

As we age, or when we are exposed to environmental stressors, our natural production of this molecule may begin to decline

Traffic 2015 , 16 , 691711

Lipid peroxidation during ferroptosis proceeds as follows: (1) the initial reaction occurs between ROS (e.g., hydroxyl radicals), that seem to be derived from NADPH oxidase rather than mitochondrial ETC, at least under some circumstances (Dixon et al., 2012), and hydrogen atoms in unsaturated lipids, typically polyunsaturated fatty acids (PUFAs)

Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation