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In contrast, dopamine depletion in other brain regions, including the locus coeruleus, thalamus, and amygdala, is associated with non-motor symptoms like depressive symptoms (Remy et al., 2005)

Given that these chiral modifications are driven by distinct chiral metabolites in cells and they may be regulated by enzymes in different ways, as well as recognized by diverse recognition proteins (or readers), the ability to differentiate between stereoisomers of PTMs holds significant importance 36

methionine cycle enzymes are enriched in many tumor types

Antidepressants commonly used in clinic, such as tricyclic antidepressants, monoamine oxidase inhibitors, selective 5-HT reuptake inhibitors, and 5-HT-norepinephrine reuptake inhibitors, have side effects as dry mouth, blurred vision, inability to drive, sexual dysfunction, headache, gastrointestinal symptoms, anxiety, and agitation (Khanam and Siddique, 2018

Obviously, following KU-57788 treatment, mitochondria in both 8505C and Hth-7 cells became irregular, with smaller spherical or short rod-like shapes, whereas mitochondria predominantly exhibited elongated or oval shapes in the control group (Fig