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The observed tendency of nonpolar substances to aggregate in an aqueous solution and exclude water molecules. Source: Hydrophobic effect

After 1 week, the patient restarted pemigatinib with further dose reduction to 4.5 mg daily

Garland-Kuntz, E

& Ablasser, A

Therefore, glutamate accumulates in the extracellular space, resulting in a large increase in the excitatory amino acid concentration (Wang et al., 2007)