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The recognition that NAD + levels fall in response to stress and can be readily replenished through supplementation has fostered great interest in the potential benefits of increasing or restoring NAD + levels in humans to prevent or delay diseases and degenerative processes

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Acknowledgements The authors express gratitude for the financial support provided by the Iran National Science Foundation (INSF) under project No.4004509, the Biotechnology Development Council of the Islamic Republic of Iran under grant No